The Endothelium
  • Author : Michel Félétou
  • Release Date : 05 February 2023
  • Publisher : Morgan & Claypool Publishers
  • Genre : Medical
  • Pages : 281
  • ISBN 13 : 9781615041237
  • Total Download : 581
  • File Size : 44,9 Mb

The Endothelium PDF Summary

"The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. "--Publisher.

The Endothelium

The Endothelium

Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
Total Download : 339
File Size : 40,7 Mb
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